Cyclodextrins permeabilize DPPC liposome membranes: a focus on cholesterol content, cyclodextrin type, and concentration

• Ghenwa Nasr,
• Hélène Greige-Gerges,
• Sophie Fourmentin,
• Abdelhamid Elaissari and
• Nathalie Khreich

Beilstein J. Org. Chem. 2023, 19, 1570–1579, doi:10.3762/bjoc.19.115

• the effect of the CD concentration on the SRB release for a specific membrane composition, while the horizontal reading of the tables highlights the impact of CHOL content on the permeability of membranes at various intervals of time. The SRB release kinetics for blank liposomes (untreated with CDs

Insight into oral amphiphilic cyclodextrin nanoparticles for colorectal cancer: comprehensive mathematical model of drug release kinetic studies and antitumoral efficacy in 3D spheroid colon tumors

• Sedat Ünal,
• Gamze Varan,
• Juan M. Benito,
• Yeşim Aktaş and
• Erem Bilensoy

Beilstein J. Org. Chem. 2023, 19, 139–157, doi:10.3762/bjoc.19.14

• cancer; camptothecin; 3D spheroid; cyclodextrin; oral nanoparticle; release kinetics; Introduction Cancer is still one of the most common, highly variable and fatal diseases worldwide. Therefore, studies are continuing to develop effective/innovative and more flexible treatments for various types of

• over 48 hours in order to clearly elucidate the release kinetics (Figure 1). An in vitro release study was carried out at 0–2 hours in simulated gastric fluid (SGF), 2–5 hours in simulated intestinal fluid (SIF), then in simulated colonic fluid (SCoF) settings till the completion of the experiment in

• assessments of this topic [9]. Release kinetics study The in vitro release profiles of CPT-loaded amphiphilic cyclodextrin nanoparticles were fitted with a variety of kinetic models, and the release mechanisms, which are illuminating markers for novel drug delivery systems, were mathematically investigated

Preparation of β-cyclodextrin/polysaccharide foams using saponin

• Max Petitjean and
• José Ramón Isasi

Beilstein J. Org. Chem. 2023, 19, 78–88, doi:10.3762/bjoc.19.7

• coronavirus vaccine chitosan–saponin coatings have been developed to study its immunogenic potential [32]. A complexation between saponin and cyclodextrins (native or derivative) is possible [33], and the resulting release kinetics is appropriate for the creation of new saponin-based drugs [34]. Their

Mechanochemical green synthesis of hyper-crosslinked cyclodextrin polymers

• Alberto Rubin Pedrazzo,
• Fabrizio Caldera,
• Marco Zanetti,
• Silvia Lucia Appleton,
• Nilesh Kumar Dhakar and
• Francesco Trotta

Beilstein J. Org. Chem. 2020, 16, 1554–1563, doi:10.3762/bjoc.16.127

• example, drug-delivery systems [3][4][5]: together with their capability of hosting drugs, they are biocompatible and nontoxic. In the last few years nanosponges were employed to encapsulate and release a wide variety of drugs [6][7], associated with an improvement in bioavailability and release kinetics

Release of β-galactosidase from poloxamine/α-cyclodextrin hydrogels

• César A. Estévez,
• José Ramón Isasi,
• Eneko Larrañeta and
• Itziar Vélaz

Beilstein J. Org. Chem. 2014, 10, 3127–3135, doi:10.3762/bjoc.10.330

• causing increased contact with the medium. Thus, the lactase activity data in acidic media for the commercial tablets could not be collected. The type of drug, its polymorphism, crystallinity, particle size and other factors can influence the release kinetics. A water-soluble drug incorporated into a

• carbonate was added to stop the reaction. The amount of yellowish o-nitrophenol (ONP) produced was analyzed by spectrophotometry (Agilent 8453 UV–vis spectrophotometer) at 416 nm. Lactase release kinetics in vitro – dissolution tests: The release from tablets and the erosion of gels was evaluated using

• absorbing considerable amounts of water, and are suitable for a variety of pharmaceutical and biomedical applications, such as drug delivery and tissue engineering. In particular, hydrogels are excellent vehicles for proteins due to their high water content, good compatibility, and controllable release

Synthesis and characterization of pH responsive D-glucosamine based molecular gelators

• Navneet Goyal,
• Hari P. R. Mangunuru,
• Bargav Parikh,
• Sonu Shrestha and
• Guijun Wang

Beilstein J. Org. Chem. 2014, 10, 3111–3121, doi:10.3762/bjoc.10.328

• the trapped drug in the gel matrix, naproxen sodium was incorporated into the gels and the release kinetics of naproxen was monitored with UV spectroscopy. The gel formed by compound 16 in DMSO/water was selected for the study, the release profiles of naproxen from the gel in the presence of water and

• cleaved under acidic conditions more easily than the benzylidene acetal group. The pH responsive gelators synthesized are stable under neutral conditions and degrade readily at acidic environment (pH 1–2). Naproxen sodium was entrapped in the gels and the release kinetics were studied. It was released

Preparation and evaluation of cyclodextrin polypseudorotaxane with PEGylated liposome as a sustained release drug carrier

• Kayoko Hayashida,
• Taishi Higashi,
• Daichi Kono,
• Keiichi Motoyama,
• Koki Wada and
• Hidetoshi Arima

Beilstein J. Org. Chem. 2014, 10, 2756–2764, doi:10.3762/bjoc.10.292

• dissolution medium system were used. The release rate constants were calculated from the slope of the appropriate plots, and the correlation coefficient (r) was also calculated (Table 3). The release kinetics of naked DOX or DOX/PEG-LP from γ-CD PPRX was well-fitted to the Higuchi’s equation with a high r

• = 590 nm (λex = 470 nm). The release kinetics of DOX or DOX/PEG-LP from the γ-CD PPRX was evaluated according to zero order kinetics, first order kinetics, Higuchi’s model, Hixson–Crowell model and Korsmeyer–Peppas’s model. Zero order kinetics where Qt is the amount of drug remaining in solid state at

Linear-g-hyperbranched and cyclodextrin-based amphiphilic block copolymer as a multifunctional nanocarrier

• Yamei Zhao,
• Wei Tian,
• Guang Yang and
• Xiaodong Fan

Beilstein J. Org. Chem. 2014, 10, 2696–2703, doi:10.3762/bjoc.10.284

• from DLMP1, DLMP2 and DLMP3 was determined by investigating their release kinetics. As can be seen from Figure 6a, there are three main stages in the complete release process of DLMP1, DLMP2 and DLMP3, ranging from 0 to 6 h, 6 to 14 h, and 24 to 36 h, respectively. Therefore, kinetic equations were

• distributions of DLMP1, DLMP2, and DLMP3 at 25 °C. Stability investigation of DLMP1, DLMP2, and DLMP3. Release profiles (a) and release kinetics (b–d) of LND from DLMP1, DLMP2 and DLMP3 in buffer solution at 37 °C. Schematic representation of the details for the construction of a multifunctional nanocarrier

Encapsulation of biocides by cyclodextrins: toward synergistic effects against pathogens

• Véronique Nardello-Rataj and
• Loïc Leclercq

Beilstein J. Org. Chem. 2014, 10, 2603–2622, doi:10.3762/bjoc.10.273

• , delivery systems based on immobilized CDs provide diffusion- or affinity-controlled release kinetics. In this mechanism, the guest biocide released from one CD may become available to form new complexes with other available CDs during the diffusion through the cross-linking matrix (Scheme 8). The diffusion

Cyclodextrin-based nanosponges as drug carriers

• Francesco Trotta,
• Marco Zanetti and
• Roberta Cavalli

Beilstein J. Org. Chem. 2012, 8, 2091–2099, doi:10.3762/bjoc.8.235

• achieve prolonged release kinetics or a faster release. The nanosponges could be used to improve the aqueous solubility of poorly water-soluble molecules, protect degradable substances, obtain sustained delivery systems or design innovative drug carriers for nanomedicine. Keywords: controlled release

• side effects. Different drug delivery systems have been designed to modify the release kinetics of medicinal products. The drug release kinetics from nanosponges can be obtained with a prolonged release profile over time. Previous in vitro studies showed that flurbiprofen was released slowly from β-CD

New amphiphilic glycopolymers by click functionalization of random copolymers – application to the colloidal stabilisation of polymer nanoparticles and their interaction with concanavalin A lectin

• Otman Otman,
• Paul Boullanger,
• Eric Drockenmuller and
• Thierry Hamaide

Beilstein J. Org. Chem. 2010, 6, No. 58, doi:10.3762/bjoc.6.58

• attention because of their potential since they represent attractive alternatives to conventional pharmaceutical applications. In addition, the size, morphology and composition of the polymer particles can be tuned to optimize the drug release kinetics in order to reduce, e.g., toxicity and improve efficacy